The invention discloses a combined comb-tooth-type cotton picker with a self-cleaning function, comprising a power-driven chain-harrow-type transmission device arranged on the upper frontal end of a rack and a cotton cleaning machine formed by a U-shaped sawtooth roller and a steel brush cotton roller; a cotton stalk pressing guide device is arranged on the rack at the front part of a picking platform; comb teeth which are mutually parallel are fixedly connected on a crossbeam evenly; the front ends of the comb teeth incline upwards; a power-driven pulling preventing roller is arranged at the rear lower part of the comb teeth; the chain-harrow-type transmission device which is matched with the comb teeth is arranged above the comb teeth; a cotton feeding roller is arranged on a discharge hole of the chain-harrow-type transmission device; the cotton cleaning device formed by the U-shaped sawtooth roller and the steel brush cotton roller is arranged below the cotton feeding roller; and a cotton collecting chamber is arranged at the rear part of the cleaning device. The cotton picker provided by the invention has no special requirements on the cotton planting mode in row space, and can be suitable for the planting mode of any row space; in the combined cotton picker, 'zero distance' transmission is implemented, thus the cotton picker has the advantages of novel and compact structure, simple and direct operational procedures, convenience in maintenance, low manufacture cost, long service life, low operational failure rate and low-impurity seed cotton and the like.