![新FER样蛋白、包含其的药物组合物及其使用方法](/CN/2009/8/20/images/200980104303.jpg)
基本信息:
- 专利标题: 新FER样蛋白、包含其的药物组合物及其使用方法
- 专利标题(英):Novel fer -like protein, pharmaceutical compositions containing it and method for its use
- 申请号:CN200980104303.5 申请日:2009-02-05
- 公开(公告)号:CN101978060A 公开(公告)日:2011-02-16
- 发明人: 乌里·尼尔 , 阿达尔·马考夫斯基 , 塞利·施庞金
- 申请人: 乌菲尔有限公司
- 申请人地址: 以色列赖阿南纳
- 专利权人: 乌菲尔有限公司
- 当前专利权人: 乌菲尔有限公司
- 当前专利权人地址: 以色列赖阿南纳
- 代理机构: 北京三友知识产权代理有限公司
- 代理人: 丁香兰
- 优先权: 61/006,897 2008.02.05 US; 61/129,112 2008.06.05 US
- 国际申请: PCT/IL2009/000136 2009.02.05
- 国际公布: WO2009/098690 EN 2009.08.13
- 进入国家日期: 2010-08-05
- 主分类号: C12N15/12
- IPC分类号: C12N15/12 ; C12N15/11 ; A61K48/00 ; A61K31/7088 ; G01N33/68 ; G01N33/574 ; A61P35/00 ; C07K14/435
The present invention provides a novel Fer-like protein, referred to herein as ''FerC'' (Fer colorectal cancer). FerC is a 47kDa protein having a unique N-terminal sequence and was found to be present in six colon cancer cell-lines and in five hepatocarcinoma (liver cancer) cell-lines, but not in CCD33 normal colon epithelial cells or normal human and mouse fibroblasts. Depletion of FerC impairs cell-cycle progression and induces apoptotic death in treated colon cancer (CC) cells. The invention also provides nucleotide sequences that are antisense to at least a portion of the N-terminal sequence, short interfering nucleotides comprising such an antisense sequence, as well as pharmaceutical compositions containing an antisense sequence. The pharmaceutical composition of the invention may be used in the treatment of cancer, in particular, colorectal cancer and liver cancer.