
基本信息:
- 专利标题: 复方瑞格列奈-盐酸二甲双胍的缓释制剂
- 专利标题(英):Slow release preparation of compound Repaglinide-metformin hydrochloride
- 申请号:CN201010118421.6 申请日:2010-03-05
- 公开(公告)号:CN101843617A 公开(公告)日:2010-09-29
- 发明人: 尹莉芳 , 王广基 , 高杨 , 黄师婧 , 张陆勇 , 陆涛 , 刘艳娥 , 张书卉
- 申请人: 中国药科大学
- 申请人地址: 江苏省南京市童家巷24号
- 专利权人: 中国药科大学
- 当前专利权人: 中国药科大学
- 当前专利权人地址: 江苏省南京市童家巷24号
- 主分类号: A61K31/451
- IPC分类号: A61K31/451 ; A61K31/155 ; A61K9/24 ; A61K9/52 ; A61P3/10
The invention relates to a slow release preparation of compound Repaglinide-metformin hydrochloride and a preparation method thereof, which mainly solve the problem of the synchronous slow release of insoluble medicament Repaglinide and water-soluble medicament metformin hydrochloride. The preparation method uses hydroxypropyl methylcellulose, glyceride behenate, ethylcellulose and the like as framework materials and comprises the steps of: respectively pelletizing the Repaglinide and the metformin hydrochloride, pressing into bilayer tablets or respectively pressing into small tablets, and encapsulating into capsules. The prepared compound slow release preparation not only can improve the curative effect based on the complementation between medicament action mechanisms and decrease the dose of each individual component to reduce toxic or side effects of the medicaments, cut also can slow down the release of the medicaments, stabilize the blood concentration, reduce the administration frequency, and improve the compliance of patients.
公开/授权文献:
- CN101843617B 复方瑞格列奈-盐酸二甲双胍的缓释制剂 公开/授权日:2012-07-18
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K31/00 | 含有机有效成分的医药配制品 |
--------A61K31/33 | .杂环化合物 |
----------A61K31/335 | ..仅有氧作为环杂原子的,例如制霉色基素 |
------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的,例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
--------------A61K31/44 | ....非稠合的吡啶;其氢化的衍生物 |
----------------A61K31/4427 | .....含另外的杂环的 |
------------------A61K31/451 | ......含有直接与杂环相连的碳环的,例如苯乙哌啶酮、杜冷丁、洛派丁胺、苯环利定、去痛定 |