The invention discloses a comprehensive simulation test platform of a large sunk shield entry-driving machine, which comprises a simulated shield entry-driving machine, a soil box, a main support device, a loading system, a monitoring system, a control system and a hydraulic system, wherein the soil box is of a sunk box-shaped structure under the ground, the inner part of the soil box is provided with a starting area, a loading area and a receiving area, the walls among the areas are provided with tunnel portals, the length, the width and the height of the soil box are respectively of 24 m, 7 m and 8.5 m, and the length, the width and the height of the loading area are respectively of 10 m, 7 m and 6.7 m; and the loading system comprises lateral loading systems arranged on the walls at the left side and the right side of the loading area of the soil box and a mobile loading system arranged at the upper part of the loading area of the soil box, the lateral loading systems and the mobile loading system are all provided with multiple loading barrels, the loading barrels are driven by the hydraulic system to extrude soil in the soil box, and the mobile loading system can fluctuate by itself and move at the upper part of the loading area of the soil box. The invention can simulate the stressed state of the soil at different depths of various strata, neglect the border effect in the simulated shield driving process, simulate the overall shield driving process in one test, and reduce the influence of the loading system damage on the test.