The invention discloses a production method of Europa suede-feel polyurethane synthetic leather, which comprises the following steps: firstly, preparing semifinished synthetic leather by using a wet method; secondly, hot-joining the polyurethane slurry layer, which is formed after the pattern of release paper is transferred, onto the surface of the semifinished synthetic leather which is printed by the wet method, wherein the polyurethane slurry comprises the following raw materials in parts by weight: polyester-polyether copolymer resin SF-01, 3-7 parts of expanded micro particle, 8-12 parts of butanone, 5-10 parts of solvent-type pigment and 0.2-0.5 part of modified silicone high polymer BYK-95950; thirdly, embossing and foaming by using embossing rollers; and finally, crinkling. The invention enables the surface of the polyurethane synthetic leather to have strong suede feel and barbing effect. The polyurethane synthetic leather has the advantages of high wear resistance, high peeling, high cold resistance, high hydrolysis resistance and other physical properties. The polyurethane synthetic leather is exactly like leather and is high-quality environmental-protection high-grade synthetic leather. The whole process conforms to the requirements of environmental protection, and conforms to the development trend of professional shoe materials in modern times.