The invention discloses a manufacture method of integrally molding a miniature assembly body, which comprises the following steps: coloring a CAD model according to material distribution characteristics of the three-dimensional CAD model of the miniature assembly body; carrying out discrete slicing lamination on the three-dimensional CAD model of the miniature assembly body to obtain a series of two-dimensional slices including molding material information and structure information; spraying molding materials layer by layer according to the structure information of the two-dimensional slices; spraying supporting materials to regions which are not sprayed by the molding materials in all layers for filling, rapidly solidifying or cooling accumulated entity materials and supporting materials to mold; and adhering and overlapping layer by layer, removing the supporting materials filled in each layer after the molding is finished to obtain the miniature assembly body corresponding to an entity model of a computer. The miniature assembly body is molded once without an assembly procedure, therefore, the method has simple procedure, low manufacture cost, broad material selection range and high manufacture precision of the miniature assembly body.