基本信息:
- 专利标题： 1位取代的四氢异喹啉化合物
- 专利标题（英）：1-substituted tetrahydroisoquinoline compound
- 申请号：CN200880016865.X 申请日：2008-05-20
- 公开(公告)号：CN101679273A 公开(公告)日：2010-03-24
- 发明人： 肉仓淳一 , 井上诚 , 荻山隆 , 米泽公一 , 山木晋 , 横山和宏 , 柿元周一郎 , 冈田英嗣
- 申请人： 安斯泰来制药株式会社
- 申请人地址： 日本东京
- 专利权人： 安斯泰来制药株式会社
- 当前专利权人： 安斯泰来制药株式会社
- 当前专利权人地址： 日本东京
- 代理机构： 北京天昊联合知识产权代理有限公司
- 代理人： 丁业平; 张天舒
- 优先权： 135452/2007 2007.05.22 JP
- 国际申请： PCT/JP2008/059287 2008.05.20
- 国际公布： WO2008/143263 JA 2008.11.27
- 进入国家日期： 2009-11-20
- 主分类号： C07D217/04
- IPC分类号： C07D217/04 ; A61K31/4355 ; A61K31/472 ; A61K31/4725 ; A61K31/4747 ; A61K31/496 ; A61P1/00 ; A61P9/00 ; A61P13/10 ; A61P25/04 ; A61P25/06 ; A61P25/10 ; A61P25/22 ; A61P25/24 ; A61P43/00 ; C07D217/14 ; C07D217/16 ; C07D221/20 ; C07D401/04 ; C07D401/06 ; C07D491/056 ; C07D401/12 ; C07D405/06
Provided is a compound useful as an N-type Ca 2+ channel blocker. As a result of intensive studies of compounds having an action of blocking N-type Ca 2+ channels, the present inventors found that a tetrahydroisoquinoline compound of the present invention having a substituent at the 1-position has an action of blocking the N-type Ca 2+ channels, an antinociceptive pain action, an antineuropathic pain action, an abdominal pain-inhibitory action and an opioid-induced constipation-improving action, and the present invention has been completed based on these findings. The compound of the present invention can be used as a pharmaceutical composition for preventing and/or treating various pains such as neuropathic pain and nociceptive pain, headaches such as migraine and cluster headache, central nervous system diseases such as anxiety, depression, epilepsy, cerebral stroke and restless legs syndrome, abdominal symptoms such as abdominal pain and abdominal distension, stool abnormalities such as diarrhea and constipation, digestive system diseases such as irritable bowel syndrome, urinary system diseases such as overactive bladder and interstitial cystitis, etc.
公开/授权文献:
- CN101679273B 1位取代的四氢异喹啉化合物 公开/授权日：2013-03-06
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D217/00 | 杂环化合物，含异喹啉或氢化异喹啉环系 |
| --------C07D217/02 | .只有氢原子或仅含碳或氢原子的基直接连在含氮环的碳原子上：烷撑-双-异喹啉 |
| ----------C07D217/04 | ..有烃基或取代的烃基连在环氮原子上 |