The invention discloses a method using the coupling of probiotic bacteria and virus for producing a medicine, which comprises the following steps: a, the protein of probiotic bacteria is taken; b, the protein of probiotic bacteria and the protein of virus are mixed at the mass ratio of 4-6:1, and EDC coupler of equal mass of the protein of probiotic bacteria and the protein of virus is added for coupling; c, the obtained coupling substance is prepared into immunogen for spare use; d, the immunogen is used for immunizing two times the heterogenic animal with the individual being bigger than the primitive virus host; e, after two-time immunization, the blood of the immunized heterogenic animal is collected for one time every other week to separate serum, HI test is used for checking the antibody titer of the virus and the probiotic bacteria, and when the antibody titer reaches 8Lg2, the blood is collected from the vein of the immunized heterogenic animal and serum is separated for spare use; f, one milliliter of the serum obtained in the step e is mixed with the suspension containing 2 billion probiotic bacteria to be stored at 4 DEG C after the 1-hour action at 37 DEG C.