基本信息:
- 专利标题： 一种肿瘤靶向荧光探针及其在肿瘤NO检测中的应用
- 专利标题（英）：Tumour targeting fluorescent probe and application in tumour NO test
- 申请号：CN200810024625.6 申请日：2008-03-28
- 公开(公告)号：CN101270342B 公开(公告)日：2011-07-20
- 发明人： 张峻峰 , 洪浩 , 张佳妮 , 欧阳杰 , 陈江宁 , 沈超 , 赵勇
- 申请人： 南京大学
- 申请人地址： 江苏省南京市汉口路22号
- 专利权人： 南京大学
- 当前专利权人： 南京大学
- 当前专利权人地址： 江苏省南京市汉口路22号
- 代理机构： 南京知识律师事务所
- 代理人： 胡锡瑜
- 主分类号： C12N1/20
- IPC分类号： C12N1/20 ; G01N21/64 ; C12Q1/02 ; C07D403/10 ; C12R1/19
The invention provides a tumor-targeted fluorescent probe, and application of the fluorescent probe in tumor NO detection, which belongs to the biotechnology field. The invention in particular relates to a fluorescent probe which can be targeted to a tumor tissue based on specificity. The fluorescent probe can form a complex with double-charge copper ions, and can be applied for the fluorescent imaging detection of the level of NO in the tumor. The fluorescent probe is the Top10 bacterial strain of colibacillus modified with N-(3-(2- phenyl imidazolyl)-4-hydroxy phenyl) maleimide. The fluorescent probe can be targeted to the tumor tissue quickly in a mammal body. In addition, the complex formed by the fluorescent probe and the double-charge copper ions can react with NO released in the tumor tissue, thus significantly improving the fluorescence intensity. In this way, the fluorescent probe can be used for the fluoroscopic detection of NO in the tumor tissue of a living body and the fluorescent imaging of the living body.
公开/授权文献:
- CN101270342A 一种肿瘤靶向荧光探针及其在肿瘤NO检测中的应用 公开/授权日：2008-09-24