
基本信息:
- 专利标题: 蒽环类药物纳米剂型及其制备方法和应用
- 专利标题(英):Anthracene nucleus medicament nano-preparation, preparation method and application thereof
- 申请号:CN200810024729.7 申请日:2008-05-12
- 公开(公告)号:CN101269223B 公开(公告)日:2011-05-04
- 发明人: 张峻峰 , 董磊 , 夏苏华 , 陈江宁
- 申请人: 南京大学
- 申请人地址: 江苏省南京市汉口路22号
- 专利权人: 南京大学
- 当前专利权人: 南京大学
- 当前专利权人地址: 江苏省南京市汉口路22号
- 代理机构: 南京知识律师事务所
- 代理人: 胡锡瑜
- 主分类号: A61K47/48
- IPC分类号: A61K47/48 ; A61K47/30 ; A61K47/36 ; A61K31/704 ; A61P35/00
摘要:
本发明属于生物医药技术领域,具体涉及阿霉素等蒽环类药物的一种纳米新制剂及其制备方法,本制剂由阿霉素等蒽环类药物、核酸和阳离子化合物组成。具体制备过程为蒽环类药物先与核酸复合,再与阳离子化合物复合形成纳米颗粒。该制剂具有降低了蒽环类药物的生理毒性而不降低其抗癌活性,具有肿瘤靶向性的特点,可以制备成治疗肿瘤的药物。
摘要(英):
The invention belongs to the biomedicine technology field, in particular relates to a new nano-preparation of anthracene-ring medicine, such as adriamycin, etc. and a preparation method thereof. The preparation is composed of anthracene-ring medicine such as adriamycin, nucleic acid, and cationic compound. The specific preparation process is that the anthracene-ring medicine is compounded with the nucleic acid firstly, and then is compounded with the cationic compound to form nano-granule. The preparation reduces the physiological toxicity of anthracene-ring medicine without reducing the anti-cancer activity, has tumor targeting characteristic and can be prepared into tumor-treating medicine.
公开/授权文献:
- CN101269223A 蒽环类药物纳米制剂及其制备方法和应用 公开/授权日:2008-09-24
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K47/00 | 以所用的非有效成分为特征的医用配制品,如载体、惰性添加剂 |
--------A61K47/48 | .非有效成分被化学键键合到有效成分上,例如聚合物药物轭合物 |