基本信息:
- 专利标题： VLP-抗原偶联物及其作为疫苗的用途
- 专利标题（英）：VLP-antigen conjugates and their uses as vaccines
- 申请号：CN200580032183.4 申请日：2005-10-05
- 公开(公告)号：CN101052411B 公开(公告)日：2011-04-06
- 发明人： M·巴克曼 , P·毛雷尔 , E·米杰林克 , K·普罗巴 , K·施瓦茨
- 申请人： 赛托斯生物技术公司
- 申请人地址： 瑞士施利伦
- 专利权人： 赛托斯生物技术公司
- 当前专利权人： 赛托斯生物技术公司
- 当前专利权人地址： 瑞士施利伦
- 代理机构： 北京市金杜律师事务所
- 代理人： 孟凡宏
- 优先权： 05105228.0 2005.06.14 EP; 60/615,637 2004.10.05 US
- 国际申请： PCT/EP2005/055009 2005.10.05
- 国际公布： WO2006/037787 EN 2006.04.13
- 进入国家日期： 2007-03-23
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/39 ; A61P31/00 ; A61P37/00
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising a virus-like particle (VLP) of an RNA-bacteriophage and at least one antigen, wherein the VLP is recombinantly produced in a host, and wherein the amount of host RNA with secondary structure comprised by the VLP is at most 20% of the amount of host RNA with secondary structure originally comprised by the VLP; and wherein the VLP and the at least one antigen are linked with one another. The invention also provides methods for producing the compositions of the invention. The compositions of the invention are useful in the production of vaccines for the treatment of diseases, disorders and conditions. Furthermore, the compositions of the invention are particularly useful to efficiently induce strong antibody responses against the antigen within the indicated context while lowering or eliminating unwanted T cell responses.
公开/授权文献:
- CN101052411A VLP－抗原偶联物及其作为疫苗的用途 公开/授权日：2007-10-10
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |