发明专利
CA2991052A1 COMPOUNDS AND COMPOSITIONS INCLUDING PHOSPHOROTHIOATED OLIGODEOXYNUCLEOTIDE, AND METHODS OF USE THEREOF
未知
基本信息:
- 专利标题： COMPOUNDS AND COMPOSITIONS INCLUDING PHOSPHOROTHIOATED OLIGODEOXYNUCLEOTIDE, AND METHODS OF USE THEREOF
- 申请号：CA2991052 申请日：2016-06-30
- 公开(公告)号：CA2991052A1 公开(公告)日：2017-01-05
- 发明人： KORTYLEWSKI MARCIN TOMASZ , SWIDERSKI PIOTR MAREK , MOREIRA DAYSON FRIACA
- 申请人： HOPE CITY
- 专利权人： HOPE CITY
- 当前专利权人： HOPE CITY
- 优先权： US201562187878 2015-07-02; US201562264026 2015-12-07
- 主分类号： A61K31/7105
- IPC分类号： A61K31/7105 ; A61K31/713 ; C07H21/02 ; C07H21/04 ; C12N15/11 ; C12N15/113
摘要：
The present disclosure relates to an isolated compound including a phosphorothioated oligodeoxynucleotide (ODN) sequence conjugated to a short-activating RNA (saRNA) or an antisense oligonucleotide sequence (ASO), compositions of such a compound, and method of treatment of cancer and autoimmune diseases (with or without stimulating immune response), method of immune stimulation, method of activating CEBPA, and method of reducing activity of STAT transcription factor, by one of the disclosed compounds or compositions.
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/70 | .碳水化合物；糖；其衍生物 |
| ----------A61K31/7088 | ..含有3个或更多个核苷或核苷酸的化合物 |
| ------------A61K31/7105 | ...天然核糖核酸，即仅含有与腺嘌呤、鸟嘌呤、胞嘧啶或尿嘧啶相连的核糖并含有3′,5′磷酸二酯键的 |