发明专利
CA1291119C 2-SUBSTITUTED ERGOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND USE THEREOF AS MEDICINAL AGENTS
未知
基本信息:
- 专利标题: 2-SUBSTITUTED ERGOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND USE THEREOF AS MEDICINAL AGENTS
- 申请号:CA478588 申请日:1985-04-04
- 公开(公告)号:CA1291119C 公开(公告)日:1991-10-22
- 发明人: SAUER GERHARD , HUTH ANDREAS , WACHTEL HELMUT , SCHNEIDER HERBERT H
- 申请人: SCHERING AG
- 专利权人: SCHERING AG
- 当前专利权人: SCHERING AG
- 优先权: DE3413657 1984-04-09; DE3413658 1984-04-09; DE3413659 1984-04-09; DE3413660 1984-04-09
- 主分类号: A61K31/475
- IPC分类号: A61K31/475 ; A61K31/48 ; A61P25/18 ; A61P25/24 ; A61P25/26 ; C07D457/02 ; C07D457/12 ; C07F7/08 ; C07F7/10 ; C07D457/00
摘要:
Novel ergoline derivatives, substituted in the 2-position, of the formula (I), wherein C8?C9 and C9?C10 each independently is a CC-single or a C=C-double bond, but not together a cumulated double bond, and the substituent in the 8-position is in the .alpha.- or .beta.-configuration where C8?C9 is a CC-single bond, R2 is CN, SR, SOR, wherein n is 2 or 3, -?R and -CH(OH)R wherein R has the meaning of H or C1-4-alkyl, the grouping COR' and CSR' wherein R' = OH, OC1-4-alkyl, benzyl, NH2 or NHR", the grouping CH=CH-CO2R" and CH2-CH2-CO2R" wherein R" = C1-4-alkyl, the grouping C?C-R''' and HC=CH-R''' wherein R''' a hydrogen, C1-4-alkyl, phenyl, CH2OH, CR"2OH, CO2R", CH2NR"2 or SiMe2R"; C1-3-alkyl, or C1-3-alkyl substituted by OH or phenyl; or wherein R" is C1-4 alkyl, R6 is C1-4-alkyl and R8 is methyl, NH-CO-NEt2 or NH-CS-NEt2, and the physiologically acceptable acid addition salt thereof, possess biological efficacy in the region of the central nervous system, e.g., as neuroleptics and antidepressants.
信息查询:
EspacenetIPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K31/00 | 含有机有效成分的医药配制品 |
--------A61K31/33 | .杂环化合物 |
----------A61K31/335 | ..仅有氧作为环杂原子的,例如制霉色基素 |
------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的,例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
--------------A61K31/47 | ....喹啉;异喹啉 |
----------------A61K31/475 | .....有吲哚环的,例如育亨宾碱、利血平、士的宁、长春花碱 |