基本信息:
- 专利标题： PLATELET AGGREGATION INHIBITORS
- 申请号：AU6036990 申请日：1990-06-15
- 公开(公告)号：AU6036990A 公开(公告)日：1991-01-08
- 发明人： SCARBOROUGH ROBERT M , WOLF DAVID LAWRENCE , CHARO ISRAEL F
- 申请人： MILLENNIUM PHARM INC
- 专利权人： MILLENNIUM PHARM INC
- 当前专利权人： MILLENNIUM PHARM INC
- 优先权： US36750989 1989-06-16; US41802889 1989-10-06; US48322990 1990-02-20
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K35/58 ; A61K38/02 ; A61K38/12 ; A61K38/17 ; A61K38/36 ; A61K38/57 ; A61P7/02 ; C07K1/14 ; C07K1/20 ; C07K7/00 ; C07K7/06 ; C07K7/64 ; C07K14/00 ; C07K14/435 ; C07K14/46 ; C07K14/745 ; C07K14/75 ; C07K14/755 ; C07K14/78 ; C12N1/21 ; C12N15/09 ; C12N15/12 ; C12P21/00 ; C12P21/02 ; C12Q1/56 ; C12R1/19 ; G01N33/86 ; A61K37/62 ; C07K1/00 ; C07K15/00 ; G01N33/566
摘要：
An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R 2 N(CH2)4CHNHCO- wherein each R is independently H, alkyl(1-6C) or at most one R is R -C=NR wherein R is H, alkyl(1-6C), phenyl or benzyl, or is NR 2 in which each R is independently H or alkyl(1-6C) and R is H, alkyl(1-6C), phenyl or benzyl, or R -C=NR is a radical selected from the group consisting of: where m is an integer of 2-3, and each R is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.
公开/授权文献:
- AU636159B2 PLATELET AGGREGATION INHIBITORS 公开/授权日：1993-04-22
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K38/00 | 含肽的医药配制品 |