基本信息:
- 专利标题： Cyclobutene derivatives, their preparation and their therapeutic uses
- 申请号：AU4875600 申请日：2000-07-21
- 公开(公告)号：AU4875600A 公开(公告)日：2001-02-01
- 发明人： KURATA HITOSHI , KOHAMA TAKAFUMI , KONO KEITA , KITAYAMA KEN
- 申请人： SANKYO CO
- 专利权人： SANKYO CO
- 当前专利权人： SANKYO CO
- 优先权： JP20716999 1999-07-22
- 主分类号： C07C211/43
- IPC分类号： C07C211/43 ; A61K31/13 ; A61K31/133 ; A61K31/135 ; A61K31/137 ; A61K31/196 ; A61K31/4409 ; A61P3/06 ; A61P9/10 ; A61P35/00 ; C07C211/40 ; C07C211/45 ; C07C211/50 ; C07C225/20 ; C07C229/16 ; C07C233/40 ; C07C233/42 ; C07C233/44 ; C07C233/78 ; C07C239/16 ; C07C251/48 ; C07C309/14 ; C07C323/32 ; C07D209/14 ; C07D209/16 ; C07D213/06 ; C07D213/38 ; C07D213/74 ; C07D333/10 ; C07D333/20 ; C07D333/36 ; C07C229/08 ; C07D213/36 ; C07D209/04 ; A61K31/381 ; A61K31/34 ; A61K31/403 ; A61K31/44 ; A61P1/16
摘要：
Compounds of formula (I): Çin which: R and R each represents a variety of organic groups; R and R each represents hydrogen or a variety of organic groups; A represents a group of formula (A-1): in which: R represents hydrogen, hydroxy or alkyl, R represents hydroxy, alkoxy, alkylthio or an amine residue, X and Y each represents oxygen or sulphur, and Z represents a direct single bond between the nitrogen atom shown and the benzene ring shown in formula (I), or an alkylene group, G represents a single bond, alkylene or substituted alkylene; the broken line represents a single or double bond; when the broken line represents a double bond, D represents a carbon atom; and E represents an =N-O- group; when the broken line represents a single bond, D represents a CH group or a nitrogen atom, and E represents an oxygen atom, a sulphur atom, an -NH- group or a -CO- group; and pharmaceutically acceptable salts, esters or other derivatives thereof have the ability to inhibit an ileal bile transporter and so may be used to treat or prevent hypercholesterolaemia.
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C211/00 | 含有与碳架连接的氨基的化合物 |
| --------C07C211/43 | .有与碳架的六元芳环的碳原子连接的氨基 |