基本信息:
- 专利标题： Novel inhibitors of beta-lactamase
- 申请号：AU2007332968 申请日：2007-05-21
- 公开(公告)号：AU2007332968B2 公开(公告)日：2013-07-11
- 发明人： VAISBURG ARKADII , CHEN HELEN , KIM SEONGKON , HERMES JEFFREY DONALD , DYKSTRA KEVIN , RAHL JUBRAIL , HAMMOND MILTON L , YOUNG KATHERINE , RAEPPEL STEPHANE , GEORGOPAPADAKOU NAFSIKA , GAUDETTE FREDERIC , DININNO FRANK , TAN QIANG , ZHOU NANCY Z , MANNION MICHAEL
- 申请人： METHYLGENE INC
- 专利权人： METHYLGENE INC
- 当前专利权人： METHYLGENE INC
- 优先权： US80214106 2006-05-22; US84000106 2006-08-25
- 主分类号： A61P31/04
- IPC分类号： A61P31/04 ; A61K31/67 ; A61K31/675 ; C07F9/6539 ; C07F9/6541 ; C07F9/6553 ; C07F9/6558 ; C07F9/6561
摘要：
This invention provides novel &bgr;-lactamase inhibitors of the aryl-and heteroarylsulfonarnidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammomium groups. The compounds inhibit three classes of &bgr;-lactamases and synergize the antibacterial effects of &bgr;-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the &bgr;-lactam antibiotics as a result of the presence of the &bgr;-lactamases. Formula (I) or pharmaceutically acceptable salt thereof.
公开/授权文献:
- AU2007332968A1 Novel inhibitors of beta-lactamase 公开/授权日：2008-06-19
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61P | 化合物或药物制剂的治疗活性 |
| ------A61P31/00 | 抗感染药，即抗生素、抗菌剂、化疗剂 |
| --------A61P31/04 | .抗细菌药 |