基本信息:
- 专利标题： JAK-2 Modulators and Methods of Use
- 申请号：AU2007305399 申请日：2007-09-28
- 公开(公告)号：AU2007305399B2 公开(公告)日：2013-09-26
- 发明人： TAKEUCHI CRAIG STACY , CHEN JEFF , JOHNSON HENRY WILLIAM BEECROFT , GALAN ADAM ANTONI , HUYNH TAI PHAT , LEE MATTHEW SANGYUP , FORSYTH TIMOTHY , MANN GRACE , LEAHY JAMES W , DU HONGWANG , ZHOU PEIWEN , KEARNEY PATRICK , RIDGWAY BRIAN HUGH
- 申请人： EXELIXIS INC
- 专利权人： EXELIXIS INC
- 当前专利权人： EXELIXIS INC
- 优先权： US84776206 2006-09-28
- 主分类号： C07D233/90
- IPC分类号： C07D233/90 ; A61K31/4178 ; A61K31/4184 ; A61P35/00 ; A61P35/02 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D405/14
摘要：
This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.
公开/授权文献:
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D233/00 | 杂环化合物，含1,3-二唑或氢化1,3-二唑环、不与其他环稠合 |
| --------C07D233/04 | .环原子间或环原子与非环原子间有1个双键 |
| ----------C07D233/66 | ..有杂原子或有以3个键连杂原子、其中最多以1个键连卤素的碳原子，例如，酯基或腈基，直接连在环碳原子上 |
| ------------C07D233/90 | ...以3个键连杂原子、其中最多以1个键连卤素的碳原子，例如酯基或腈基 |