基本信息:
- 专利标题： Benzimidazole derivatives
- 申请号：AU2002332178 申请日：2002-09-18
- 公开(公告)号：AU2002332178B2 公开(公告)日：2005-12-08
- 发明人： NISHIOKA HIROYASU , MORITA HITOSHI , MIURA NAOYOSHI , NAGASAWA MASAAKI , SHINOZAKI YUTAKA , ASAMI KAZUYASU
- 申请人： ZERIA PHARM CO LTD
- 专利权人： ZERIA PHARM CO LTD
- 当前专利权人： ZERIA PHARM CO LTD
- 优先权： JP2002096101 2002-03-29; JP2001282918 2001-09-18
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; A61P1/04 ; C07D401/12 ; A61K031/4439 ; A61P001/04
摘要：
A benzimidazole derivative of formula (1): (wherein R represents a hydrogen atom or a methoxy group, and n is 0 or 1) or a salt thereof; and a medicament containing the same. The compounds of the present invention, due to minimized difference in therapeutic effect between subjects, which difference would otherwise be derived from different CYP2C19 activity from subject to subject, ensure that all patients can enjoy proper therapeutic effects at the same dose of the drug. Also, the compounds of the invention have low risk of drug interaction caused by induction of CYP1A family member enzymes, as well as low risk of development of cancer, and thus is useful as a remedy for peptic ulcer, reliably providing therapeutic effects with safety.
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/44 | ....非稠合的吡啶；其氢化的衍生物 |
| ----------------A61K31/4427 | .....含另外的杂环的 |
| ------------------A61K31/4439 | ......含有氮作为环杂原子的五元环的，例如奥美拉唑 |