发明专利
AU2002246650A1 Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation
未知
基本信息:
- 专利标题： Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation
- 申请号：AU2002246650 申请日：2001-12-12
- 公开(公告)号：AU2002246650A1 公开(公告)日：2002-08-06
- 发明人： SEGEV ORIT , BAR DGANIT , FEINSTEIN ELENA
- 申请人： QUARK BIOTECH INC , SHIONOGI AND CO LTD
- 专利权人： QUARK BIOTECH INC,SHIONOGI AND CO LTD
- 当前专利权人： QUARK BIOTECH INC,SHIONOGI AND CO LTD
- 优先权： US25485000 2000-12-12
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; A61K31/13 ; A61K31/155 ; A61K31/16 ; A61K31/275 ; A61K31/52 ; A61K31/70 ; A61K31/7076 ; A61K45/00 ; A61P19/02 ; A61P43/00 ; C12N9/99 ; C12Q1/02 ; C12Q1/48 ; C12Q1/527 ; G01N33/15 ; A01N43/04
摘要：
This invention provides a method for the treatment of a subject in need of treatment for osteoarthritis comprising administering to said subject an amount of an inhibitor of spermidine biosynthesis sufficient to effect a substantial inhibition of spermidine biosynthesis. This invention also provides the use of an inhibitor of spermidine biosynthesis in the treatment of a subject in need of treatment of osteoarthritis in an amount sufficient to effect a substantial inhibition of spermidine biosynthesis This invention further provides a method of preparing a therapeutic composition for the treatment of a subject in need of a treatment for osteoarthritis and the invention further provides a method identifying an inhibitor of spermidine biosynthesis, whereby the inhibitor is a spermidine synthesis inhibitor.